Hydroxychloroquine is Bad for COVID-19 Patients According to Peer Reviewed Study in The Lancet

More good news for Trump and the Trumpists. Apparently, hydroxychloroquine, when given to COVID-19 patients, does not help, and actually increases the risk of death in those patients.

A peer reviewed study in The Lancet, a highly respected medical journal, came to that conclusion after studying 15,000 patients who had COVID-19 and were treated with Hydroxychloroquine, or Chloroquine, or one of those two drugs with antibiotics as well.

From the CNN article on the findings in The Lancet peer reviewed study:

Researchers analyzed data from more than 96,000 patients with confirmed Covid-19 from 671 hospitals. All were hospitalized from late December to mid-April, and had died or been discharged by April 21.

Just below 15,000 patients were treated with the antimalarial drugs hydroxychloroquine or chloroquine, or one of those drugs combined with an antibiotic.

All four of those treatments were linked with a higher risk of dying in the hospital. About 1 in 11 patients in the control group died in the hospital. About 1 in 6 patients treated with chloroquine or hydroxychloroquine alone died in the hospital. About 1 in 5 treated with chloroquine and an antibiotic died and almost 1 in 4 treated with hydroxychloroquine and an antibiotic died.

Researchers also found that serious cardiac arrhythmias were more common among patients receiving any of the four treatments. The largest increase was among the group treated with hydroxychloroquine and an antibiotic; 8% of those patients developed a heart arrhythmia, compared with 0.3% of patients in the control group.


https://www.cnn.com/us/live-news/us-coronavirus-update-05-22-20/h_a5569b9e019b7c5f2d0c916b21bc0959

Apparently this news may be too late for the United States Veterans' Administration, which has treated at least 1,300 veterans with Hydroxychloroquine for COVID-19, according to an article in The Hill today.

https://thehill.com/policy/defense/499166-va-gave-hydroxychloroquine-for-covid-19-to-1300-veterans

Oh well, what is a few more dead veterans, anyway. They were probably all pretty old, and as the Cult Leader said, about to die.

Comments

  • Lancet is pulling the study back. It's based on a lot of personal opinion and tainted data.
  • That’s true. Another highly respected medical journal is also withdrawing a published article for the same reason. Does that mean that hydroxychloroquine is a good treatment for COVID-19?
  • Let the highly-trained scientists sort it out. Research takes time and requires confirmation from multiple studies.

    In the meantime, the ignorant and arrogant U.S. President needs to keep his crazy opinions to himself. He has no idea what he is talking about.
  • Science seems to have reached a consensus on the efficacy of hydroxychloroquine for the treatment of COVID-19, literally as well as scientifically. In an article published two days ago, five days after The Lancet and the New England Journal of Medicine withdrew their published studies due to problems with data manipulation, Science published an article on three newer studies, all of which conclude that hydroxychloroquine is ineffective for treating COVID-19. These three new studies apparently have solid data behind them. So it appears the scientific community is concluding that hydroxychloroquine is not a proper treatment for the disease.

    On 5 June, researchers in the United Kingdom announced the results from the largest trial yet, Recovery, in a press release. In a group of 1542 hospitalized patients treated with hydroxychloroquine, 25.7% had died after 28 days, compared with 23.5% in a group of 3132 patients who had only received standard care. “These data convincingly rule out any meaningful mortality benefit,” wrote the investigators, who ended the study early and promised to publish the full results as soon as possible.

    https://www.sciencemag.org/news/2020/06/three-big-studies-dim-hopes-hydroxychloroquine-can-treat-or-prevent-covid-19

    Also from the article in Science:

    Another hope for hydroxychloroquine, that it might prevent people exposed to the virus from getting sick, also faded last week when David Boulware of the University of Minnesota, Twin Cities, and colleagues published the results of the largest study to date of this strategy, called postexposure prophylaxis (PEP). The researchers sent either hydroxychloroquine or a placebo by mail to 821 people who had been in close contact with a COVID-19 patient for more than 10 minutes without proper protection. They reported in The New England Journal of Medicine that 12% of the people who took the drug went on to develop COVID-19 symptoms, versus 14% in a placebo group, a difference that was not statistically significant.

    A second large PEP trial has come up empty as well, its leader tells Science. Carried out in Barcelona, Spain, that study randomized more than 2300 people exposed to the virus to either hydroxychloroquine or the usual care. There was no significant difference between the number of people in each group who developed COVID-19, says Oriol Mitjà of the Germans Trias i Pujol University Hospital. Mitjà says he has submitted the results for publication.

    If you, your spouse, your mother gets admitted to hospital and is offered hydroxychloroquine, don’t take it.
    Martin Landray, University of Oxford

    The data are important because they come from large randomized trials. So far, most data came from small trials or case series. A meta-analysis of 24 such studies published in the Annals of Internal Medicine concluded there was “insufficient and often conflicting evidence on the benefits and harms of using hydroxychloroquine or chloroquine to treat COVID-19.”
  • So a new study has just been released (and in the news this morning) regarding the effectiveness of hydroxychloroquine. It's reported that "In-hospital mortality was 18.1 percent with both drugs, 13.5 percent with just hydroxychloroquine, 22.4 percent with azithromycin alone, and 26.4 percent with neither drug. The researchers say "Prospective trials are needed for further review, the researchers note.
  • America is heavily religious,anti-science,& filled with conspiracy crackpots so.... ¯\_(ツ)_/¯.MERICA HELL YEAH!.
  • marc, where is this alleged "new study?" Post the link so that we can read it for ourselves.

    In the meantime, I will trust the U.S. FDA's advice: "Currently there are no FDA-approved medicines specifically approved for the treatment or prevention of COVID-19."

    https://www.fda.gov/emergency-preparedness-and-response/coronavirus-disease-2019-covid-19/covid-19-frequently-asked-questions
  • Just do a quick search for: "Henry Ford Health Study" and you'll find a lot of references to it.
  • Here is an article on the study, involving more than 2,000 hospitalized patients, from the Henry Ford Health System:

    https://www.henryford.com/news/2020/07/hydro-treatment-study

    Following is a quote from the article;

    Dr. Zervos also pointed out, as does the paper, that the study results should be interpreted with some caution, should not be applied to patients treated outside of hospital settings and require further confirmation in prospective, randomized controlled trials that rigorously evaluate the safety and efficacy of hydroxychloroquine therapy for COVID-19.

    “Currently, the drug should be used only in hospitalized patients with appropriate monitoring, and as part of study protocols, in accordance with all relevant federal regulations,” Dr. Zervos said.


    Here is a link to the study itself. I wasn't allowed to post it separately:

    https://www.ijidonline.com/article/S1201-9712(20)30534-8/fulltext
  • Apparently the study itself is not recoverable. Note that the link above is not complete, and when clicked it indicates an error has occurred. Although I cannot say for sure, this may have to do with copyright issues involving the International Journal of Infectious Diseases, which published the study, or with the lack of completeness of the published study. For those who wish to read the study, it can be found as a link in the henryford.com article linked to above.
  • To be clear on this issue, I welcome any medicine or therapy that saves the lives of Covid-19 patients.

    That said, and because all drugs have side effects, the positive benefits must always be weighed against the negative effects, and that requires extensive testing over time. I trust that time-consuming but generally reliable process.

    In the meantime, we already KNOW how to slow the pandemic and save lives: Wear a face mask when you leave your house, stay away from large crowds, and sanitize surfaces touched by other people.

    In other words, do just the opposite of what President Trump does.


  • FM, yes, we can "do just the opposite of what President Trump does". One issue that you probably have in mind is the wearing of mask. President Trump chooses not to wear mask all the time because people that he meets are "tested" just before they come and meet him; and they have proven that they have no infection.

    He also practices social distancing as much as possible. Whereas the regular people need to wear mask when they come close to people who have not been tested.
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